Antipsychotics, also known as neuroleptics, are a class of medications primarily used to manage symptoms of psychosis. Psychosis is a mental health condition characterised by a disconnection from reality, which can manifest as hallucinations, delusions, disrupted thought patterns, and impaired insight. Antipsychotic drugs work by modulating neurotransmitter activity, particularly dopamine, in the brain to alleviate symptoms associated with various psychiatric disorders, including schizophrenia and bipolar disorder.
Classification of Antipsychotic Drugs
1. Typical Antipsychotics (First-generation):
Examples: Haloperidol, Chlorpromazine, Fluphenazine.
Mechanism: Primarily block dopamine D2 receptors.
Side effects may include extrapyramidal symptoms (EPS).
2. Atypical Antipsychotics (Second-generation):
Examples: Risperidone, Olanzapine, Quetiapine, Aripiprazole.
Mechanism: Affect both dopamine and serotonin receptors.
Associated with a lower risk of EPS but may have metabolic side effects.
 Pharmacological Actions of Antipsychotic Drugs
1. Dopamine Receptor Blockade:
Antipsychotics exert their therapeutic effects by blocking dopamine receptors, particularly D2 receptors.
2. Serotonin Receptor Modulation:
Atypical antipsychotics also modulate serotonin receptors, contributing to their overall pharmacological actions.
3. Stabilization of Neurotransmitter Activity:
Antipsychotics help regulate neurotransmitter imbalances in the brain, restoring a more stable and functional state.
 Dose
1. Dosage Varies:
The dosage of antipsychotic drugs varies based on the specific medication, the patient’s age, weight, and the severity of symptoms.
 Indications
1. Psychosis:
Antipsychotics are indicated for the management of psychotic symptoms, including hallucinations and delusions.
2. Schizophrenia:
Primary use in the treatment of schizophrenia, a severe mental disorder characterised by disordered thoughts, emotions, and perceptions.
3. Bipolar Disorder:
Antipsychotics may be used in the treatment of acute manic or mixed episodes in bipolar disorder.
4. Major Depressive Disorder (Adjunctive):
Some atypical antipsychotics are used as adjunctive therapy in major depressive disorder.
5. Agitation and Aggression:
Healthcare professionals may prescribe antipsychotics to manage severe agitation or aggression in various psychiatric conditions.
Contraindications
1. Allergy:
Contraindicated in individuals with a known allergy to the specific antipsychotic drug.
2. QT Prolongation:
Individuals with a history of QT prolongation should exercise caution as some antipsychotics have the potential to prolong the QT interval.
3. Neuroleptic Malignant Syndrome (NMS):
Antipsychotics should be avoided in individuals with a history of neuroleptic malignant syndrome.
4. Severe Central Nervous System Depression:
Contraindicated in conditions associated with severe central nervous system depression.
5. Parkinson’s Disease:
Individuals with Parkinson’s disease need to exercise caution due to the risk of exacerbating Parkinsonian symptoms.
6. Dementia-Related Psychosis:
Increased risk of mortality in elderly patients with dementia-related psychosis.
It’s crucial for healthcare professionals to carefully evaluate the specific indications, potential benefits, and risks when prescribing antipsychotic medications. Regular monitoring for side effects, including metabolic effects, is important, and adjustments to the treatment plan may be necessary based on individual patient response and tolerability.
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