Bitter almond: Introduction, Composition, Chemistry, Bio-Sources, Therapeutic Uses, and Commercial Applications

1. Introduction of Bitter almond

Bitter almond (Prunus dulcis var. amara) is a variety of almond known for its distinct bitter taste and high amygdalin content. Unlike sweet almonds, bitter almonds contain cyanogenic glycosides, which release hydrogen cyanide upon enzymatic hydrolysis. While toxic in large quantities, bitter almonds have been historically used for medicinal, flavoring, and cosmetic purposes. They are primarily cultivated in Mediterranean regions and parts of the Middle East.

Bitter almond

2. Composition of Bitter Almond

Bitter almonds contain several bioactive compounds that contribute to their distinct characteristics and medicinal properties:

Cyanogenic Glycosides

  • Amygdalin (Laetrile)
  • Prunasin

Fixed Oils

  • Oleic acid
  • Linoleic acid
  • Palmitic acid

Volatile Compounds

  • Benzaldehyde (responsible for the characteristic bitter almond aroma)

Proteins and Vitamins

  • Rich in proteins and essential amino acids
  • Contains vitamin E and antioxidants

3. Chemistry of Bitter Almond

It owe their characteristic properties to cyanogenic glycosides, particularly amygdalin.

Breakdown of Amygdalin

Upon hydrolysis by the enzyme beta-glucosidase, amygdalin releases:

  • Benzaldehyde (responsible for the almond fragrance)
  • Hydrogen cyanide (HCN) (toxic in large doses)

Chemical Properties of Benzaldehyde

  • Molecular Formula: C₆H₅CHO
  • Known for its antimicrobial properties and role in flavoring agents.

4. Bio-Sources of Almond

Geographic Distribution

  • Mediterranean Region: Spain, Italy, Greece
  • Middle East: Iran, Turkey
  • North America: California, USA

Cultivation and Harvesting

  • Requires a warm, temperate climate
  • Harvested when fully mature to ensure optimal oil content

5. Therapeutic Uses of Bitter Almond

Sedative and Pain Relief: It contain amygdalin, which can be converted into hydrogen cyanide in the body. In controlled medicinal doses, bitter almond extracts have been traditionally used as a mild sedative and pain reliever. It has been used to soothe nerve pain and muscle spasms. However, due to its toxicity, it must be used cautiously and under medical supervision.

Antitussive and Respiratory Benefits: It oil has been historically used in traditional medicine for respiratory conditions such as cough, asthma, and bronchitis. It is believed to help clear mucus and ease breathing difficulties. Some herbal formulations include bitter almond extracts for their potential cough-suppressant properties.

Antimicrobial and Antifungal Properties: The essential oil of thes has demonstrated antimicrobial and antifungal effects. It has been used externally to treat skin infections and fungal conditions. The oil is sometimes added to medicinal ointments for its ability to combat bacteria and fungi.

Digestive Aid and Appetite Stimulation: In some traditional practices, it have been used in very small amounts to aid digestion and stimulate appetite. However, due to their potential toxicity, they should not be consumed raw or in large quantities. Bitter almond extract is sometimes used in herbal medicine to support digestive health.

Skin and Hair Care: It oil is used in cosmetics for its emollient properties, helping to moisturize and soften the skin. It is also used in hair treatments to promote shine and reduce scalp irritation. However, due to its toxicity, bitter almond oil used for cosmetic purposes is usually processed to remove harmful compounds.

Precautions and Toxicity: It contain cyanogenic glycosides, which release hydrogen cyanide when ingested. Consumption of raw bitter almonds in large quantities can be fatal. For this reason, many countries regulate or ban the sale of raw bitter almonds. Only processed bitter almond extracts that have been detoxified are considered safe for consumption. Pregnant and breastfeeding women, children, and individuals with respiratory or cardiac conditions should avoid bitter almonds due to their potential toxicity. Always consult a healthcare professional before using bitter almond products for medicinal purposes.

6. Commercial Applications of Almond

Pharmaceutical Industry

  • Used in cough syrups and expectorants.
  • Studied for potential anti-cancer applications.

Cosmetic Industry

  • Bitter almond oil is used in skincare formulations due to its emollient and antioxidant properties.
  • Found in lotions, soaps, and anti-aging creams.

Food and Flavoring Industry

  • Benzaldehyde derived from bitter almonds is widely used in:
    • Bakery products
    • Confectionery
    • Liqueurs (e.g., Amaretto)

Aromatherapy and Perfumery

  • Bitter almond oil is utilized in essential oil blends for relaxation and therapeutic applications.

7. Safety, Toxicity, and Precautions

Cyanide Toxicity Concerns

  • Excessive consumption can lead to cyanide poisoning.
  • Processed bitter almond products are regulated to minimize toxicity risks.

Safe Dosage Considerations

  • Used in trace amounts in food and pharmaceuticals.
  • Bitter almond oil should be used externally unless specifically processed for consumption.

Contraindications

  • Not recommended for children, pregnant women, or individuals with liver disorders.

Conclusion

Bitter almonds, despite their toxicity concerns, offer significant medicinal, cosmetic, and commercial applications. Their unique chemical composition, particularly amygdalin and benzaldehyde, contributes to their antimicrobial, antioxidant, and therapeutic properties. With proper processing and usage, bitter almond extracts continue to hold value in various industries, from pharmaceuticals to perfumery. Further research may unlock additional therapeutic potentials while ensuring safety in consumption and application.

Leave a Reply

Your email address will not be published. Required fields are marked *

Related Post

Screenshot 2023 12 06 192654 Neuroglia- Definition, Types, Functions

Neuroglia- Definition, Types, Functions

Glia, also known as glial cells or neuroglia, play an active role in maintaining homeostasis in the central nervous system (CNS), which includes the brain and spinal cord, as well as the peripheral nervous system. Glia, non-neuronal cells, do not generate electrical impulses themselves. The neuroglia definition underscores their contribution to supporting and defending neurons […]

Screenshot 2024 07 12 131122 Central Nervous System (CNS) Stimulants: Definition, Classification, Mechanism of action, uses and Side effects

Central Nervous System (CNS) Stimulants: Definition, Classification, Mechanism of action, uses and Side effects

 Definition CNS stimulants are a class of drugs that enhance the activity of the brain and spinal cord, leading to increased alertness, energy, and attention. They can affect various neurotransmitters and are used therapeutically for conditions such as attention deficit hyperactivity disorder (ADHD), narcolepsy, and certain cases of depression.  Classification of Central Nervous System (CNS) […]

Screenshot 2023 12 23 174413 Registration of pharmacists

Registration of pharmacists

Registration of pharmacists is a crucial aspect of the regulatory framework in the pharmacy field. It involves the formal process through which individuals who have completed the requisite qualifications and training are officially recognized and listed in the register maintained by pharmacy regulatory authorities. The registration of pharmacists is governed by laws and regulations to […]