Unit 4 Archives - Pharmaacademias

Type of incompatibility—physical, chemical, and therapeutic—with examples

March 21, 2025November 29, 2023 by DeepakRajput

Incompatibility refers to an undesirable reaction that occurs when two or more substances—such as drugs, excipients, or solvents—are mixed, resulting in unintended changes in their physical, chemical, or therapeutic properties. These changes can significantly impact the safety, efficacy, and stability of pharmaceutical formulations, leading to potential therapeutic failure or harmful effects. Incompatibility can arise at … Read more

Pharmaceutical incompatibilities- Definition, Classification

November 29, 2023 by DeepakRajput

Pharmaceutical incompatibilities refer to undesirable reactions or interactions between pharmaceutical ingredients, such as drugs, excipients, or formulation components. These interactions can result in physical, chemical, or therapeutic changes that may compromise the pharmaceutical product’s stability, efficacy, or safety. Incompatibilities can occur during the formulation, manufacturing, storage, or administration of pharmaceuticals. Pharmaceutical incompatibilities can be classified … Read more

Evaluation of suppositories

November 29, 2023 by DeepakRajput

The evaluation of suppositories involves assessing various physical, chemical, and performance characteristics to ensure their quality, efficacy, and safety. Here are key aspects considered during the evaluation of suppositories: 1. Physical Characteristics Appearance: Check for uniformity in size, shape, and color. Look for any cracks, discoloration, or other visual defects. Surface Texture: Assess the smoothness … Read more

Displacement value of suppository’s & its calculations

November 29, 2023 by DeepakRajput

The displacement value measures a suppository’s volume in a molded cavity or mold. It is an important parameter in suppository formulation and manufacturing, as it helps ensure accurate dosing of the active ingredient. The displacement value is often expressed as a percentage and is calculated using the formula: Here’s a step-by-step guide on how to … Read more

Preparation of suppositories

November 29, 2023 by DeepakRajput

The preparation of suppositories involves several methods, and the choice of method depends on factors such as the type of base, the active ingredient, and the desired characteristics of the suppository. Here are some common methods of suppository preparation: 1. Fusion or Molding Method Procedure: The base is melted, and the active ingredient is incorporated … Read more

Types of bases for suppositories

November 29, 2023 by DeepakRajput

Suppositories are formulated with various bases that provide the appropriate consistency, melting or dissolution characteristics, and compatibility with the active ingredients. The choice of base depends on factors such as the suppository’s intended use and the drug’s properties. Common types of bases for suppositories include: 1. Fatty or Oleaginous Bases Examples: Cocoa butter (Theobroma oil), … Read more

Suppositories – Definition, Types, Advantages and Disadvantages

March 21, 2025November 29, 2023 by DeepakRajput

Suppositories are solid, medicated dosage forms designed for insertion into body orifices, typically the rectum or vagina, where they gradually melt, dissolve, or disperse. They are formulated to deliver therapeutic substances, such as medications or lubricants, to mucous membranes or for systemic absorption through the rectal or vaginal walls. Suppositories come in various shapes, sizes, … Read more