1. Physical Incompatibilities Definition: Physical incompatibility refers to changes in a pharmaceutical product’s physical appearance or state. Examples: Precipitation: Insoluble particles formed when two solutions are mixed. For example, mixing calcium-containing intravenous solutions with phosphate-containing solutions may lead to calcium phosphate precipitation. Phase Separation: Separation of components into distinct phases. …
DeepakRajput 
Pharmaceutical incompatibilities- Definition, Classification
Pharmaceutical incompatibilities refer to undesirable reactions or interactions between pharmaceutical ingredients, such as drugs, excipients, or formulation components. These interactions can result in physical, chemical, or therapeutic changes that may compromise the pharmaceutical product’s stability, efficacy, or safety. Incompatibilities can occur during the formulation, manufacturing, storage, or administration of pharmaceuticals. …
Evaluation of suppositories
The evaluation of suppositories involves assessing various physical, chemical, and performance characteristics to ensure their quality, efficacy, and safety. Here are key aspects considered during the evaluation of suppositories: 1. Physical Characteristics Appearance: Check for uniformity in size, shape, and color. Look for any cracks, discoloration, or other visual defects. …
Displacement value of suppository’s & its calculations
The displacement value measures a suppository’s volume in a molded cavity or mold. It is an important parameter in suppository formulation and manufacturing, as it helps ensure accurate dosing of the active ingredient. The displacement value is often expressed as a percentage and is calculated using the formula: Here’s a …
Preparation of suppositories
The preparation of suppositories involves several methods, and the choice of method depends on factors such as the type of base, the active ingredient, and the desired characteristics of the suppository. Here are some common methods of suppository preparation: 1. Fusion or Molding Method Procedure: The base is melted, and …
Types of bases for suppositories
Suppositories are formulated with various bases that provide the appropriate consistency, melting or dissolution characteristics, and compatibility with the active ingredients. The choice of base depends on factors such as the suppository’s intended use and the drug’s properties. Common types of bases for suppositories include: 1. Fatty or Oleaginous Bases …
Suppositories – Definition, Types, Advantages and Disadvantages
Suppositories are solid, medicated dosage forms designed for insertion into body orifices, typically the rectum or vagina, where they gradually melt, dissolve, or disperse. They are formulated to deliver therapeutic substances, such as medications or lubricants, to mucous membranes or for systemic absorption through the rectal or vaginal walls. Suppositories …
