Paroxetine – Definition, Uses, Mechanism

Paroxetine is an antidepressant medication that belongs to the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). It is commonly prescribed to treat various mood disorders.

Uses

1. Major Depressive Disorder (MDD): Paroxetine is widely prescribed for the treatment of major depressive disorder.

2. Obsessive-compulsive disorder (OCD): It is used in the management of obsessive-compulsive disorder.

3. Panic Disorder: Paroxetine is indicated for the treatment of panic disorder.

4. Social Anxiety Disorder: It may be prescribed for social anxiety disorder.

5. Generalized anxiety: Paroxetine can be used in the treatment of generalized anxiety disorder.

6. Post-Traumatic Stress Disorder (PTSD): It is used for post-traumatic stress disorder.

7. Premenstrual Dysphoric Disorder (PMDD): Paroxetine may be prescribed for PMDD.

Mechanism of Action

Paroxetine works by selectively inhibiting the serotonin reuptake in the brain, leading to increased levels of serotonin in the synaptic cleft and improved mood.

Dosage Forms

1. Tablets: Paroxetine is commonly available in tablet form.

2. Oral Suspension: Liquid formulations are available for individuals with difficulty swallowing tablets.

Common Brand Names

1. Paxil: Paxil is a well-known brand name for paroxetine.

Dosage and Administration:

Paroxetine dosage varies based on the individual’s condition and response to treatment. It is usually taken orally, with or without food.

Storage Conditions:

 Paroxetine should be stored in a cool, dry place, protected from light. Specific storage instructions may vary based on the pharmaceutical formulation.

Stability:

 The stability of paroxetine is generally maintained under proper storage conditions. It’s important to check the expiration date on the medication packaging and not use expired medication.

Common Side Effects

 Side effects may include nausea, insomnia, dry mouth, and sexual dysfunction. Any persistent or severe side effects should be reported to the healthcare provider.

Contraindications

 Paroxetine is contraindicated in individuals with a known hypersensitivity to the drug and in those taking or recently discontinuing monoamine oxidase inhibitors (MAOIs).

As with any medication, individuals should use paroxetine only under the guidance and prescription of a qualified healthcare professional. Following the prescribed dosage, attending regular follow-up appointments, and communicating any concerns or side effects to the healthcare provider are crucial.

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