Parkinson’s Disease: In 1817, British physician Dr. James Parkinson published a case series documenting six patients suffering from “shaking palsy” (paralysis agitans), a chronic and progressive neurological disorder now known as Parkinson’s disease (PD). Parkinson’s disease occurs when nerve cells in the substantia nigra, a part of the brain, deteriorate or become damaged. These cells … Read more
Dopamine is a crucial neurotransmitter and hormone that plays vital roles in the central nervous system and peripheral tissues. It is involved in several key physiological processes including motor control, motivation, reward, and regulation of mood. Dopamine dysregulation is implicated in various neurological and psychiatric disorders. This note provides a comprehensive overview of dopamine synthesis, … Read more
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that primarily affects movement. It is characterized by the loss of dopamine-producing neurons in the substantia nigra region of the brain, leading to motor and non-motor symptoms. Etiopathogenesis: 1. Dopamine Depletion: Progressive loss of dopamine-producing neurons in the substantia nigra. 2. Lewy Bodies: Accumulation of abnormal protein … Read more
