Therapeutic Incompatibilities

Type of incompatibility—physical, chemical, and therapeutic—with examples

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1. Physical Incompatibilities Definition: Physical incompatibility refers to changes in a pharmaceutical product’s physical appearance or state. Examples: Precipitation: Insoluble particles formed when two solutions are mixed. For example, mixing calcium-containing intravenous solutions with phosphate-containing solutions may lead to calcium phosphate precipitation. Phase Separation: Separation of components into distinct phases. In liquid formulations, such as … Read more

Pharmaceutical incompatibilities- Definition, Classification

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Pharmaceutical incompatibilities refer to undesirable reactions or interactions between pharmaceutical ingredients, such as drugs, excipients, or formulation components. These interactions can result in physical, chemical, or therapeutic changes that may compromise the pharmaceutical product’s stability, efficacy, or safety. Incompatibilities can occur during the formulation, manufacturing, storage, or administration of pharmaceuticals. Pharmaceutical incompatibilities can be classified … Read more

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